منابع مشابه
Antibodies for strain 2117-like vesiviruses (caliciviruses) in humans.
The vesivirus strain 2117 has been identified as contaminant of bioreactors used for production of human drugs, due to possible contamination of the reagents used for cell cultivation. Using an ELISA assay, antibodies specific for 2117-like viruses were detected in 32/410 (7.8%) human sera, indicating exposure to these viruses.
متن کاملBiol. Pharm. Bull. 28(11) 2117—2119 (2005)
methylation in azathioprine (AZA), thioguanine and 6-mercaptopurine (6-MP). The low TPMT activity in erythrocytes has been associated with an increased risk of severe and potentially fatal hematopoietic toxicity caused by the accumulation of the cytotoxic metabolites of thiopurine drugs. Genetic polymorphism of the TPMT activity in human was first reported by Weinshilboum and Sladek. Four varia...
متن کامل2117 Correlations between the optical power of human corneal grafts before and after transplantation
Purpose. The purpose of this study ws~s to evaluate We changes of the refractive error in the follow up after penetrating keratoplasty for Fuchs’ dystrophy. Methods. Between 1960 and 1991 16.2 keratoplasties with mechanical trephination and single running suture ware performed for Fuchs’ dystrophy consecutively. The suture was removed 20,4 f 7.5 months postoperatively. In 99 eyes a simultaneous...
متن کاملAsteroseismological constraints on the pulsating planetary nebula nucleus ( PG 1159 - type ) RX J 2117 . 1 + 3412
Aims. We present asteroseismological inferences on RXJ2117.1+3412, the hottest known pulsating PG1159 star. Our results are based on full PG1159 evolutionary models recently presented by Miller Bertolami & Althaus (2006). Methods. We performed extensive computations of adiabatic g-mode pulsation periods on PG1159 evolutionary models with stellar masses ranging from 0.530 to 0.741M⊙. PG1159 stel...
متن کاملVesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures
Vesivirus 2117 is an adventitious agent that, in 2009, was identified as a contaminant of Chinese hamster ovary cells propagated in bioreactors at a pharmaceutical manufacturing plant belonging to Genzyme. The consequent interruption in supply of Fabrazyme and Cerezyme (drugs used to treat Fabry and Gaucher diseases, respectively) caused significant economic losses. Vesivirus 2117 is a member o...
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ژورنال
عنوان ژورنال: Journal of Clinical and Translational Science
سال: 2017
ISSN: 2059-8661
DOI: 10.1017/cts.2017.244